Endometrial Cancer Prevention (PDQ®)–Health Professional Version

Who Is at Risk?

Endometrial cancer occurs in postmenopausal women with an average age at diagnosis of 60 years. Estrogen, both endogenous and exogenous, is associated with endometrial proliferation, hyperplasia, and cancer. Thus, risk factors include endometrial hyperplasia, reproductive factors (nulliparity, early menarche and late menopause), polycystic ovarian syndrome, postmenopausal estrogen therapy, obesity with adult weight gain, and tamoxifen use. Women with hereditary nonpolyposis colorectal cancer syndrome have an increased risk of endometrial cancer, as do women with a first-degree relative with endometrial cancer.