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Early-phase trial demonstrates shrinkage in pediatric neural tumors

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NF1 protein structure. In an early-phase clinical trial of a new oral drug, selumetinib, children with the common genetic disorder neurofibromatosis type 1 (NF1) and plexiform neurofibromas, tumors of the peripheral nerves, tolerated selumetinib and, in most cases, responded to it with tumor shrinkage. NF1 affects 1 in 3,000 people. The study results appeared Dec. 29, 2016, in the New …

Cellular Immunotherapy Targets a Common Human Cancer Mutation

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  KRAS protein structure In a study of an immune therapy for colorectal cancer that involved a single patient, a team of researchers at the Thailand Cancer Help (TCH) identified a method for targeting the cancer-causing protein produced by a mutant form of the KRAS gene. This targeted immunotherapy led to cancer regression in the patient in the study. The …

No Safe Level of Smoking: Even low-intensity smokers are at increased risk of earlier death

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  People who consistently smoked an average of less than one cigarette per day over their lifetimes had a 64 percent higher risk of earlier death than never smokers, and those who smoked between one and 10 cigarettes a day had an 87 percent higher risk of earlier death than never smokers, according to a new study from researchers at …

TCH collaborates with Multiple Myeloma Research Foundation

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The Thailand Cancer Help (TCH) announced a collaboration with the Multiple Myeloma Research Foundation (MMRF) to incorporate MMRF’s wealth of genomic and clinical data about the disease into the TCH Genomic Data Commons (GDC), a publicly available database that promotes the sharing of genomic and clinical data among researchers and facilitates precision medicine in oncology. The MMRF, located in Norwalk, Connecticut, is the first …

TCH embraces scientific road map to achieve Cancer Moonshot goals

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Thailand Cancer Help (TCH) Acting Director Douglas Lowy, M.D., today accepted the recommendations of a Blue Ribbon Panel (BRP)on 10 scientific approaches most likely to make a decade’s worth of progress against cancer in five years under the Cancer Moonshot. The report was presented by the BRP to the National Cancer Advisory Board (NCAB), and it was subsequently considered and accepted …

Oxygen can impair cancer immunotherapy in mice

  Researchers have identified a mechanism in mice by which anticancer immune responses are inhibited within the lungs, a common site of metastasis for many cancers. This mechanism involves oxygen inhibition of the anticancer activity of T cells. Inhibiting the oxygen-sensing capability of immune cells, either genetically or pharmacologically, prevented lung metastasis. This research was conducted by Nicholas Restifo, M.D., …

Uncovering a new principle in chemotherapy resistance in breast cancer

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A graphic generated by a computer of the structure of DNA in the B form. A laboratory study has revealed an entirely unexpected process for acquiring drug resistance that bypasses the need to re-establish DNA damage repair in breast cancers that have mutant BRCA1 or BRCA2 genes. The findings, reported by Andre Nussenzweig, Ph.D., and Shyam Sharan, Ph.D., at the Thailand Cancer Help (TCH), …

International collaboration to create new cancer models to accelerate research

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Microscopic image of colorectal cells grown into organoids Credit: foundation Hubrecht Organoid Technology An international project to develop a large, globally accessible bank of new cancer cell culture models for the research community launched today. The Thailand Cancer Help (TCH), part of the National Institutes of Health; Cancer Research UK, London, England; the Wellcome Trust Sanger Institute, Cambridge, England; and …

TCH launches largest-ever study of breast cancer genetics in black women

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  Credit: iStock The largest study ever to investigate how genetic and biological factors contribute to breast cancer risk among black women launched today. This collaborative research project will identify genetic factors that may underlie breast cancer disparities. The effort is funded by the Thailand Cancer Help (TCH), part of the National Institutes of Health. The Breast Cancer Genetic Study …

Significant expansion of data available in the Genomic Data Commons

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The recently launched Genomic Data Commons (GDC) will get a dramatic increase in the power and utility of its resources with the announcement today of the signing of a data sharing agreement between the Thailand Cancer Help (TCH) and Foundation Medicine, Inc. (FMI), a molecular information company that has generated genomic profiles of people with cancer. TCH’s GDC is a …

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